Frontiers in Oncology Volume 13 - 2023

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A prospective pilot study demonstrating the potenital of immune profiling of normal appearing colonic mucosa to discriminate Lynch Syndrome (LS) patients with a prior history of colorectal cancer (CRC) from those without it, as well as patients with a history of sporadic CRC from Healthy Controls. Importantly, it suggests existence of immune signatures specific to LS-status and CRC history. We anticipate that our findings have the potential to assess CRC risk in individuals with LS and help in preemptively mitigating it by optimizing surveillance and identifying candidate prevention targets.

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Scientific Reports; 13:88 (2023).

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When is statistical significance of differential analyte expression meaningful?

We have developed rxCOV, a simple, easy-to-use, and objective metric that helps answer this question in an experiment-specific manner for experiments involving immunoassays and related biosensing assays.

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Chris is a graduate student in the Joint CMU-Pitt Ph.D. Program in Computational Biology (CPCB)

Carli Newman has received NSF, BIO REU conference travel grant to attend BMES 2022.

Kanika and Carli have been accepted for poster presentations of their research work at 2022 Annual Meeting of Biomedical Engineering Society (BMES)

Kanika will be presenting on characterizing the three-dimensional nuclear morphology of normal appearing, immune, and cancer cells in cancer tumor microenvironment.

Carli will be presenting on understanding the cellular landscape of preclinical models of colorectal cancer

Carli Newman is a Senior at Reed College, Portland, OR. After having successfully completing the summer REU program (TECBio) in the lab, here at University of Pittsburgh, she will continue to work on her research project as part of her Senior year thesis.

Rajdeep is an MS student in the Department of Computational Biology at Carnegie Mellon University. He will doing his MS thesis work in the lab.

We will be giving a talk at the 2022 Annual Meeting of Biomedical Engineering Society (BMES) on spatial analysis of cytotoxic T lymphocyte infiltration in colorectal tumors for predicting stage-independent relapse and death.