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December 1, 2020

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks

S. Uttam*, A. M. Stern, S. Furman, F. Pullara, D. Spagnolo, L. Nguyen, A. H Gough, C. Sevinsky, F. Ginty, D. L. Taylor, S. C. Chennubhotla* (Co-corresponding authors)

Nat. Commun.; 1:3515 (2020).

Our study utilizes highly multiplexed immunofluorescence imaging and spatial systems biology to predict risk of colorectal cancer recurrence, and identify emergent spatial domain networks and the spatial dependence of the consensus molecular subtypes of cancerassociated with this recurrence.