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January 26, 2022

Prediction of neoplastic progression in Barrett’s esophagus using nanoscale nuclear architecture mapping: A pilot study

P. Thota*, J. Nasibli, P. Kumar, M. R. Sanaka, A. Chak, X. Zhang, X. Liu, S. Uttam*, Y. Liu* (* Co-corresponding authors)

Gastrointestinal Endoscopy; 95(6):1239-1246 (2022).

We utilized the ability of nanoscale nuclear architecture mapping (nanoNAM) to detect with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation, to identify patients with Barrett’s esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).